Selective sphingosine-1-phosphate receptor modulator etrasimod
Selective sphingosine-1-phosphate receptor modulator etrasimod
Etrasimod (APD334) is an oral, selective sphingosine-1-phosphate receptor modulator. It was evaluated in the randomised, double-blind, placebo-controlled, parallel-group, phase 2 OASIS study in patients with moderately to severely active ulcerative colitis [1]. Etrasimod 2 mg induced significantly higher rates of endoscopic improvement, histological improvement and remission, and mucosal healing in ulcerative colitis patients compared with placebo.
The 156 participants were randomised to once-daily etrasimod 1 mg (n=52), 2 mg (n=50), or placebo (n=54); 90% of patients completed the study. At week 12, etrasimod 2 mg, compared with placebo, resulted in significantly higher rates of:
- endoscopic improvement (43.2% vs 16.3%; P=0.003);
- histological improvement (31.7% vs 10.2%; P=0.006);
- histological remission (19.5% vs 6.1%; P=0.027).
Mucosal healing (defined as both endoscopic improvement and histological remission) was seen in 19.5% and 4.1% of patients treated with etrasimod 2 mg and placebo, respectively (P=0.010). The authors think mucosal healing may prove to be an achievable and objective measure of drug efficacy in ulcerative colitis induction studies.
Keywords: ulcerative colitis, endoscopy
- Peyrin-Biroulet L, et al. ECCO 2019, OP09.
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