Highlights from

ECCO 2019

European Crohn's and Colitis Organisation's 14th congress

Copenhagen 6-9 March 2019

Network analysis of GWAS

Greek researchers reported on their use of a novel approach that ranks proteins and signalling pathways associated with inflammatory bowel disease (IBD) phenotypes by disease implication [1]. This provided new insights into IBD’s molecular background, and highlights targets of potential diagnostic and therapeutic value. They performed a network analysis of GWAS of an extended cohort of 573 Greek IBD patients (364 with Crohn’s disease and 209 with ulcerative colitis) and 445 controls. They implicated 89 loci in IBD risk. Also, distinct functional pathways associated with each of the 2 IBD forms and their phenotypes were identified. For most of the IBD susceptibility loci, the direction and magnitude of effect were consistent in IBD cohorts. Phenotype-specific functional interaction networks, through centrality analysis, revealed well known IBD-related genes and their interactors.

Keywords: Crohn’s disease, ulcerative colitis

  1. Gazouli M, et al. ECCO 2019, P828.

Top image: © Pornpak Khunatorn

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